CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation
CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Hsp104 is a ring-forming AAA+ machine that recognizes both aggregated proteins and prion-fibrils as substrates and, together with the Hsp70 system, remodels substrates in an ATP-dependent manner. Whereas the ability to disaggregate proteins is dependent on the Hsp104 M-domain, the location of the M-domain is controversial and its exact function rem...
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Full title
CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation
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TN_cdi_proquest_miscellaneous_733184116
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733184116
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1003572107
