Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in...
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
About this item
Full title
Author / Creator
Bernhardt, W.M , Gottmann, U , Doyon, F , Buchholz, B , Campean, V , Schödel, J , Reisenbuechler, A , Klaus, S , Arend, M , Flippin, L , Willam, C , Wiesener, M.S , Yard, B , Warnecke, C and Eckardt, K.-U
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Long-term survival of renal allografts depends on the chronic immune response and is probably influenced by the initial injury caused by ischemia and reperfusion. Hypoxia-inducible transcription factors (HIFs) are essential for adaptation to low oxygen. Normoxic inactivation of HIFs is regulated by oxygen-dependent hydroxylation of specific prolyl-...
Alternative Titles
Full title
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_733347895
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733347895
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0903978106
