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Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation...

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_73364419

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

About this item

Full title

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2003-06, Vol.9 (6), p.744-749

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Antigen-specific immune responses in the skin are initiated by antigen uptake into Langerhans cells and the subsequent migration of these cells to draining lymph nodes. Although prostaglandin E
2
(PGE
2
) is produced substantially in skin exposed to antigen, its role remains unclear. Here we show that although Langerhans cells express a...

Alternative Titles

Full title

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_73364419

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_73364419

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/nm872

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