T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experiment...
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
About this item
Full title
Author / Creator
Axtell, Robert C , de Jong, Brigit A , Boniface, Katia , van der Voort, Laura F , Bhat, Roopa , De Sarno, Patrizia , Naves, Rodrigo , Han, May , Zhong, Franklin , Castellanos, Jim G , Mair, Robert , Christakos, Athena , Kolkowitz, Ilan , Katz, Liat , Killestein, Joep , Polman, Chris H , de Waal Malefyt, René , Steinman, Lawrence and Raman, Chander
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Interferon-β (IFN-β) is a mainstay therapy for multiple sclerosis. However, only two thirds of patients respond to therapy, and clinical symptoms worsen in some patients. Chandar Raman and his colleagues show that IFN-β alleviates disease induced by T helper type 1 cells and exacerbates disease induced by T helper type 17 cells in mice. They also s...
Alternative Titles
Full title
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
Authors, Artists and Contributors
Author / Creator
de Jong, Brigit A
Boniface, Katia
van der Voort, Laura F
Bhat, Roopa
De Sarno, Patrizia
Naves, Rodrigo
Han, May
Zhong, Franklin
Castellanos, Jim G
Mair, Robert
Christakos, Athena
Kolkowitz, Ilan
Katz, Liat
Killestein, Joep
Polman, Chris H
de Waal Malefyt, René
Steinman, Lawrence
Raman, Chander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_733864520
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733864520
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2110
