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The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity

The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733903395

The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity

About this item

Full title

The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (42), p.17858-17863

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through t...

Alternative Titles

Full title

The Interaction of TIGIT with PVR and PVRL2 Inhibits Human NK Cell Cytotoxicity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_733903395

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_733903395

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0903474106

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