HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
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Author / Creator
Yanai, Hideyuki , Ban, Tatsuma , Wang, ZhiChao , Choi, Myoung Kwon , Kawamura, Takeshi , Negishi, Hideo , Nakasato, Makoto , Lu, Yan , Hangai, Sho , Koshiba, Ryuji , Savitsky, David , Ronfani, Lorenza , Akira, Shizuo , Bianchi, Marco E. , Honda, Kenya , Tamura, Tomohiko , Kodama, Tatsuhiko and Taniguchi, Tadatsugu
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
HMGB protein sentinels
The chromosomal HMGB (high-mobility group box) proteins HMGB1, HMGB2 and HMGB3 are shown here to be essential for all nucleic-acid receptor-mediated activation of innate immune responses. HMGBs bound to all immunogenic nucleic acids tested — whether considered ligands for Toll-like receptors or for cytosolic receptors — su...
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Full title
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
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TN_cdi_proquest_miscellaneous_734125314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_734125314
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08512
