Diverse backbone-cyclized peptides via codon reprogramming
Diverse backbone-cyclized peptides via codon reprogramming
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
We report a methodology for the ribosomal synthesis of backbone-cyclized peptides involving genetic code reprogramming to introduce one or more nonproteinogenic amino acids. Expression of linear peptides bearing a cysteine-proline dipeptide sequence followed by glycolic acid results in self-rearrangement to a C-terminal diketopiperadine-thioester,...
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Full title
Diverse backbone-cyclized peptides via codon reprogramming
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TN_cdi_proquest_miscellaneous_734141950
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_734141950
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.259
