Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Contents
The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression. Phosphopeptide affinity proteomic analysis identified a protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-Ser-X-X-Phe motif. Abraxas binds BRCA1 to the mutual exclusion of BACH1 (BRCA1-associated C-termina...
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Full title
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
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TN_cdi_proquest_miscellaneous_743103731
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743103731
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1139476
