CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility
CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of age. Mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or immune complexes. Electron microscopic analysis of...
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Full title
CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility
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TN_cdi_proquest_miscellaneous_743114966
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743114966
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1081068
