Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines
Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines
About this item
Full title
Author / Creator
Publisher
Washington, DC: American Society for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Society for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The function of the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor can be regulated by extracellular pH, a process that may be important during ischemia in the brain or during seizures. Protons inhibit NMDA receptor function by 50 percent at pH 7.3 through interactions with the NR1 subunit, and both polyamines and NR1 exon 5 potentiate r...
Alternative Titles
Full title
Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_743149131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743149131
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.7754371
