Crystal structure of opsin in its G-protein-interacting conformation
Crystal structure of opsin in its G-protein-interacting conformation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Opsin, the ligand-free form of the G-protein-coupled receptor rhodopsin, at low pH adopts a conformationally distinct, active G-protein-binding state known as Ops*. A synthetic peptide derived from the main binding site of the heterotrimeric G protein—the carboxy terminus of the α-subunit (GαCT)—stabilizes Ops*. Here we present the 3.2 Å crystal st...
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Full title
Crystal structure of opsin in its G-protein-interacting conformation
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TN_cdi_proquest_miscellaneous_743152964
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743152964
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature07330
