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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743161567

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

About this item

Full title

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Author / Creator

Valente, Enza Maria , Abou-Sleiman, Patrick M. , Caputo, Viviana , Miratul M. K. Muqit , Harvey, Kirsten , Gispert, Suzana , Ali, Zeeshan , Del Turco, Domenico , Bentivoglio, Anna Rita , Healy, Daniel G. , Albanese, Alberto , Nussbaum, Robert , González-Maldonado, Rafael , Deller, Thomas , Salvi, Sergio , Cortelli, Pietro , Gilks, William P. , Latchman, David S. , Harvey, Robert J. , Dallapiccola, Bruno , Auburger, Georg and Wood, Nicholas W.

Publisher

United States: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2004-05, Vol.304 (5674), p.1158-1160

Language

English

Formats

Articles

Publication information

Publisher

United States: American Association for the Advancement of Science

Subjects

More information

Scope and Contents

Contents

Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare familial form of PD to chromosome 1p36 (PARK6). Here we show that mutations in PINK1 (PTEN-induced kinase 1) are associated with PARK6. We have identified two homozygous muta...

Alternative Titles

Full title

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_743161567

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743161567

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1096284

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