MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Hepatocellular carcinoma is generally refractory to clinical treatment
1
. Here, we report that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers. MYC inactivation resulted
en masse
in tumour cells differentiating into hepatocytes and biliary cells forming bile duct structures, and t...
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Full title
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
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TN_cdi_proquest_miscellaneous_743312594
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743312594
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature03043
