Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel...
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Full title
Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
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TN_cdi_proquest_miscellaneous_743322449
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743322449
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1106215
