Structure of the apoptotic protease-activating factor 1 bound to ADP
Structure of the apoptotic protease-activating factor 1 bound to ADP
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Apoptosis is executed by caspases, which undergo proteolytic activation in response to cell death stimuli
1
. The apoptotic protease-activating factor 1 (Apaf-1) controls caspase activation downstream of mitochondria
2
. During apoptosis, Apaf-1 binds to cytochrome
c
and in the presence of ATP/dATP forms an apoptosome, leading to...
Alternative Titles
Full title
Structure of the apoptotic protease-activating factor 1 bound to ADP
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TN_cdi_proquest_miscellaneous_743482941
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743482941
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature03465
