Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
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Washington, DC: American Society for the Advancement of Science
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Language
English
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Washington, DC: American Society for the Advancement of Science
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Contents
Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome. This effect, rather than depending on ligand-induced receptor oligomerization, was found to stem from ligand-independent interaction of wild-type and mutant Fas recepto...
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Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
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TN_cdi_proquest_miscellaneous_743675049
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743675049
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.288.5475.2354
