Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
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Author / Creator
Minowa, O. , Ikeda, K. , Sugitani, Y. , Oshima, T. , Nakai, S. , Katori, Y. , Suzuki, M. , Furukawa, M. , Kawase, T. , Zheng, Y. , Ogura, M. , Asada, Y. , Watanabe, K. , Yamanaka, H. , Gotoh, S. , Nishi-Takeshima, M. , Sugimoto, T. , Kikuchi, T. , Takasaka, T. and Noda, T.
Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Washington, DC: American Society for the Advancement of Science
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Contents
DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor. Brn-4-deficient mice were created and found to exhibit profound deafness. No gross morphological changes were observed in the conductive ossicles or cochlea, although there was a dramatic reduction in endococ...
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Full title
Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
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Record Identifier
TN_cdi_proquest_miscellaneous_743688277
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743688277
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.285.5432.1408
