Regulation of Lineage Commitment Distinct from Positive Selection
Regulation of Lineage Commitment Distinct from Positive Selection
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Scope and Contents
Contents
Developing αβ T cells diverge into the CD4 and CD8 lineages as they mature in the thymus. It is unclear whether lineage commitment is mechanistically distinct from the process that selects for the survival of T cells with useful T cell receptor (TCR) specificities (positive selection). In HD mice, which lack mature CD4$^+$ T cells, major histocompa...
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Full title
Regulation of Lineage Commitment Distinct from Positive Selection
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TN_cdi_proquest_miscellaneous_743740839
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743740839
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.286.5442.1149
