Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin- 2 Receptor β
Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin- 2 Receptor β
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Contents
In mice lacking the interleukin-2 receptor β chain (IL-2Rβ), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells and the appearance of high serum concentrations of immunoglobulins G1 and E as well as autoantibodies that cause hemolytic anemia. Marked infiltrative granulocytopoiesis...
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Full title
Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin- 2 Receptor β
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TN_cdi_proquest_miscellaneous_745701219
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_745701219
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.7770771
