Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cl...
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Many proteases are important drug targets, but identification of their substrates remains challenging. By using polymers to selectively isolate N-terminal peptides generated by proteolysis of complex samples, Kleifeld
et al
. identify substrates of clinically relevant proteases with broad specificity.
Effective proteome-wide strategies tha...
Alternative Titles
Full title
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_746160938
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_746160938
Other Identifiers
ISSN
1087-0156,1546-1696
E-ISSN
1546-1696
DOI
10.1038/nbt.1611
