Bordetella Adenylate Cyclase Toxin Mobilizes Its b2 Integrin Receptor into Lipid Rafts to Accomplish...
Bordetella Adenylate Cyclase Toxin Mobilizes Its b2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps
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English
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Bordetella adenylate cyclase toxin (CyaA) binds the aMb2 integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP. We show that penetration of the AC domain across cell membrane proceeds in two steps. It starts by membrane inser...
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Bordetella Adenylate Cyclase Toxin Mobilizes Its b2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps
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TN_cdi_proquest_miscellaneous_746232180
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_746232180
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1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1000901
