Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk...
Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest
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Author / Creator
Chan, Q K Y , Lam, H-M , Ng, C-F , Lee, A Y Y , Chan, E S Y , Ng, H-K , Ho, S-M and Lau, K-M
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
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Scope and Contents
Contents
G-protein-coupled receptor-30 (GPR30) shows estrogen-binding affinity and mediates non-genomic signaling of estrogen to regulate cell growth. We here showed for the first time, in contrast to the reported promoting action of GPR30 on the growth of breast and ovarian cancer cells, that activation of GPR30 by the receptor-specific, non-estrogenic lig...
Alternative Titles
Full title
Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest
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Record Identifier
TN_cdi_proquest_miscellaneous_748953544
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_748953544
Other Identifiers
E-ISSN
1476-5403
DOI
10.1038/cdd.2010.20
