Targeting the ANGPT–TIE2 pathway in malignancy
Targeting the ANGPT–TIE2 pathway in malignancy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key Points
The angiopoietin (ANGPT)–TIE system is crucial for the angiogenic switch in tumours, and together with vascular endothelial growth factor A (VEGFA) promotes the initiation of angiogenesis and maturation of new vessels. The ANGPT–TIE system is also involved in inflammation, metastasis and lymphangiogenesis.
ANGPT1 is a TIE2 agonist,...
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Full title
Targeting the ANGPT–TIE2 pathway in malignancy
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TN_cdi_proquest_miscellaneous_754533700
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754533700
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc2894
