A direct role for Hsp90 in pre-RISC formation in Drosophila
A direct role for Hsp90 in pre-RISC formation in Drosophila
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Previously, the molecular chaperone Hsp90 has been shown to copurify with RISC (RNA-induced silencing complex), involved in small RNA-mediated silencing. It is now shown that Hsp90 is needed for AGO2 to be loaded with a siRNA duplex by the RISC-loading complex suggesting a model where it is involved in modifying AGO2 conformation.
Heat-shock pro...
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Full title
A direct role for Hsp90 in pre-RISC formation in Drosophila
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TN_cdi_proquest_miscellaneous_754539755
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754539755
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ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/nsmb.1875
