Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the the...
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
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Author / Creator
Raje, N , Hideshima, T , Mukherjee, S , Raab, M , Vallet, S , Chhetri, S , Cirstea, D , Pozzi, S , Mitsiades, C , Rooney, M , Kiziltepe, T , Podar, K , Okawa, Y , Ikeda, H , Carrasco, R , Richardson, P G , Chauhan, D , Munshi, N C , Sharma, S , Parikh, H , Chabner, B , Scadden, D and Anderson, K C
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cyclin D dysregulation and overexpression is noted in the majority of multiple myeloma (MM) patients, suggesting its critical role in MM pathogenesis. Here, we sought to identify the effects of targeting cyclin D in MM. We first confirmed cyclin D mRNA overexpression in 42 of 64 (65%) patient plasma cells. Silencing cyclin D1 resulted in >50% apopt...
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Full title
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
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Record Identifier
TN_cdi_proquest_miscellaneous_754884512
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754884512
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2008.378
