Development of a modeling framework to simulate efficacy endpoints for motesanib in patients with th...
Development of a modeling framework to simulate efficacy endpoints for motesanib in patients with thyroid cancer
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Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
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Scope and Contents
Contents
Purpose To develop a modeling framework that simulates clinical endpoints (objective response rate and progression-free survival) to support development of motesanib. The framework was evaluated using results from a phase 2 study of motesanib in thyroid cancer. Methods Models of probability and duration of dose modifications and overall survival we...
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Full title
Development of a modeling framework to simulate efficacy endpoints for motesanib in patients with thyroid cancer
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Record Identifier
TN_cdi_proquest_miscellaneous_759133419
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_759133419
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ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-010-1449-z
