Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver–chimeric mouse model. The results provide evidence that bro...
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Full title
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
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TN_cdi_proquest_miscellaneous_759317663
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_759317663
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1698
