Upregulation of CTLA-4 by HIV-specific CD4 super(+) T cells correlates with disease progression and...
Upregulation of CTLA-4 by HIV-specific CD4 super(+) T cells correlates with disease progression and defines a reversible immune dysfunction
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English
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In progressive viral infection, antiviral T cell function is impaired by poorly understood mechanisms. Here we report that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus (HIV)-specific CD4 super(+) T cells but not CD8 super(+) T cells in all categories of HIV-infected subjects evaluated,...
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Upregulation of CTLA-4 by HIV-specific CD4 super(+) T cells correlates with disease progression and defines a reversible immune dysfunction
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TN_cdi_proquest_miscellaneous_762278597
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762278597
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ISSN
1529-2908
E-ISSN
1365-2567
DOI
10.1038/ni1515
