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High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without s...

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without s...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762279365

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

About this item

Full title

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

Publisher

New York: Nature Publishing Group US

Journal title

Nature genetics, 2001-06, Vol.28 (2), p.147-150

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Researchers in several laboratories have reported a high frequency of homoplasmic mitochondrial DNA (mtDNA) mutations in human tumors
1
,
2
,
3
,
4
,
5
,
6
. This observation has been interpreted to reflect a replicative advantage for mutated mtDNA copies
1
,
2
,
6
, a growth advantage for a cel...

Alternative Titles

Full title

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_762279365

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762279365

Other Identifiers

ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.1038/88859

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