Interaction of IL-2R$\beta$ and $\gamma_c$ Chains with Jak1 and Jak3: Implications for XSCID and XCI...
Interaction of IL-2R$\beta$ and $\gamma_c$ Chains with Jak1 and Jak3: Implications for XSCID and XCID
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Washington, DC: American Society for the Advancement of Science
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English
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Washington, DC: American Society for the Advancement of Science
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Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor $\beta$ (IL-2R$\beta$) and common $\gamma$ ($\gamma_c$) chains. Mutations of $\gamma_c$ can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain $\gamma_c$), and IL-9 (whose receptor is shown here to contain $...
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Full title
Interaction of IL-2R$\beta$ and $\gamma_c$ Chains with Jak1 and Jak3: Implications for XSCID and XCID
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TN_cdi_proquest_miscellaneous_76838919
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_76838919
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.7973658
