Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Contents
Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing βARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of β-adrener...
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Full title
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
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TN_cdi_proquest_miscellaneous_77294288
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_77294288
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.7761854
