Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Contents
The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissue, and amounts of serum immunoglobulin were elevat...
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Full title
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
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TN_cdi_proquest_miscellaneous_77665461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_77665461
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.270.5238.985
