Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The susceptibility of xenografts to hyperacute rejection is postulated to reflect in part failure of complement regulatory proteins (CRPs) to control activation of heterologous complement on graft endothelium. To test this concept, transgenic swine expressing the human CRP decay accelerating factor and CD59 were developed using a novel expression s...
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Full title
Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
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TN_cdi_proquest_miscellaneous_77696413
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_77696413
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm0595-423
