Major Histocompatibility Complex Class I–Restricted Infiltration and Destruction of Pancreatic Islet...
Major Histocompatibility Complex Class I–Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived β-Cell Cytotoxic CD8+ T-Cell Clones In Vivo
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Author / Creator
Publisher
Alexandria, VA: American Diabetes Association
Journal title
Language
English
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Publication information
Publisher
Alexandria, VA: American Diabetes Association
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Scope and Contents
Contents
NOD mouse-derived β-cell-specific cytotoxic T-cell (β-CTL) clones are diabetogenic in adult NOD mice, but only if co-injected with splenic CD4+ T-cells from diabetic animals. This investigation was initiated to determine whether infiltration of pancreatic islets by β-CTL is a major histocompatibility complex (MHC) class I-restricted response, and w...
Alternative Titles
Full title
Major Histocompatibility Complex Class I–Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived β-Cell Cytotoxic CD8+ T-Cell Clones In Vivo
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Record Identifier
TN_cdi_proquest_miscellaneous_78194474
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_78194474
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/diab.45.8.1121