Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by a paucity of adipose (fat) tissue which is evident at birth and is accompanied by a severe resistance to insulin, leading to hyperinsulinaemia, hyperglycaemia and enlarged fatty liver. We have developed a mouse model that mimics these features of CGL:...
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Full title
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
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TN_cdi_proquest_miscellaneous_787362213
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_787362213
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/43448
