The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Scope and Contents
Contents
In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear morphology. Bcl-2 acted in situ on mitochondria to prevent the release of cytochrome c and thus caspase activation. During apoptosis in intact cells, cytochrome c translocation w...
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Full title
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
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TN_cdi_proquest_miscellaneous_78827185
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_78827185
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.275.5303.1132
