The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both d-alanyl-d-alanine...
The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both d-alanyl-d-alanine and d-alanyl-d-lactate ligases
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Abstract
High level resistance to vancomycin and other glycopeptide antibiotics requires the synthesis of peptidoglycan terminating in the depsipeptide d-Ala-d-lactate, rather than the usual d-Ala-d-Ala. We report the purification and enzymatic characterization of two d-Ala ligases from Streptomyces toyocaensis NRRL 15009 which produces the glyc...
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Full title
The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both d-alanyl-d-alanine and d-alanyl-d-lactate ligases
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Record Identifier
TN_cdi_proquest_miscellaneous_79521552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_79521552
Other Identifiers
ISSN
0378-1097
E-ISSN
1574-6968
DOI
10.1111/j.1574-6968.1997.tb12788.x