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Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal inj...

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal inj...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_80080627

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

About this item

Full title

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

Publisher

New York: Elsevier Inc

Journal title

Laboratory investigation, 2004-01, Vol.84 (1), p.21-28

Language

English

Formats

Publication information

Publisher

New York: Elsevier Inc

More information

Scope and Contents

Contents

There is a growing body of evidence implicating complement and, in particular, the terminal pathway (membrane attack complex; MAC) in inducing demyelination in multiple sclerosis and experimental allergic encephalomyelitis. In this paper, we examined the disease course and pathological changes in mice deficient in the major regulator of MAC assembl...

Alternative Titles

Full title

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_80080627

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_80080627

Other Identifiers

ISSN

0023-6837

E-ISSN

1530-0307

DOI

10.1038/labinvest.3700015

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