Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Poly(ADP-ribose) polymerase 1 (PARP-1) and p53 are two key proteins in the DNA-damage response. Although PARP-1 is known to poly(ADP-ribosyl)ate p53, the role of this modification remains elusive. Here, we identify the major poly(ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly(ADP-ribosyl)ation blocks the interaction betw...
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Full title
Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
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TN_cdi_proquest_miscellaneous_807271351
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_807271351
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1638
