Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
IRGM is a human GTPase that triggers autophagy in response to pathogen infection. On Mycobacteria infection, IRGM binds the mitochondrial cardiolipin to induce mitochondrial fission and a general autophagy response. It can also trigger autophagy-independent mitochondria-mediated cell death.
IRGM, a human immunity-related GTPase, confers autophag...
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Full title
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
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TN_cdi_proquest_miscellaneous_815961707
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_815961707
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2119
