ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma...
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
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Author / Creator
KLINE, M. P , RAJKUMAR, S. V , TIMM, M. M , KIMLINGER, T. K , HAUG, J. L , LUST, J. A , GREIPP, P. R and KUMAR, S
Publisher
London: Nature Publishing
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Language
English
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Publisher
London: Nature Publishing
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Contents
Disruption of pathways leading to programmed cell death plays a major role in most malignancies, including multiple myeloma (MM). ABT-737 is a BH3 mimetic small-molecule inhibitor that binds with high affinity to Bcl-2 and Bcl-xL, preventing the sequestration of proapoptotic molecules and shifting the cell survival/apoptosis balance toward apoptosi...
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Full title
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
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TN_cdi_proquest_miscellaneous_817602634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_817602634
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/sj.leu.2404719
