Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acut...
Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
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Author / Creator
Tonks, A , Pearn, L , Musson, M , Gilkes, A , Mills, K I , Burnett, A K and Darley, R L
Publisher
England: Nature Publishing Group
Journal title
Language
English
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Publisher
England: Nature Publishing Group
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Scope and Contents
Contents
The t(8;21)(q22;q22) occurs frequently in acute myelogenous leukaemia and gives rise to the transcription factor fusion protein, RUNX1-RUNX1T1 (also known as AML1-ETO). To identify the genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression in huma...
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Full title
Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
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Record Identifier
TN_cdi_proquest_miscellaneous_817604068
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_817604068
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/sj.leu.2404961
