miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
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Author / Creator
Wang, Jian-Xun , Jiao, Jian-Qin , Li, Qian , Long, Bo , Wang, Kun , Liu, Jin-Ping , Li, Yan-Rui and Li, Pei-Feng
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Jian-Xun Wang
et al
. show that mitochondrial fission, which occurs during cell death, is regulated in cardiomyocytes by the microRNA miR-499 through a mechanism involving the phosphatase calcineurin and its substrate Drp1. Overexpression of miR-499 was able to reduce mitochondrial fission and apoptosis in the hearts of mice or rats injured b...
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Full title
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
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Record Identifier
TN_cdi_proquest_miscellaneous_835118040
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_835118040
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2282
