Pax5: the guardian of B cell identity and function
Pax5: the guardian of B cell identity and function
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage 'inappropriate' genes and simultaneously activating B lineage–specific genes. This transcriptional reprogramming restricts the broad signaling capacity of uncommitted progenitors to the B ce...
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Full title
Pax5: the guardian of B cell identity and function
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Record Identifier
TN_cdi_proquest_miscellaneous_851461453
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_851461453
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1454
