Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-...
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Mast cells are key effector cells in allergic reactions. Aggregation of the receptor FcεRI in mast cells triggers the influx of calcium (Ca
2+
) and the release of inflammatory mediators. Here we show that transient receptor potential TRPM4 proteins acted as calcium-activated nonselective cation channels and critically determined the driving...
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Full title
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4
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TN_cdi_proquest_miscellaneous_851461542
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_851461542
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ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1441
