Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic str...
Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme γ-secretase showed reduced damage to brain cells and improved functional outcome in a model of focal ischemic stroke. Notch endangers neurons by modulating pathways that increase their vulnerability to apoptosis, and by activating microglial c...
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Full title
Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
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TN_cdi_proquest_miscellaneous_853478903
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_853478903
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1403
