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Bace1 modulates myelination in the central and peripheral nervous system

Bace1 modulates myelination in the central and peripheral nervous system

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_856760190

Bace1 modulates myelination in the central and peripheral nervous system

About this item

Full title

Bace1 modulates myelination in the central and peripheral nervous system

Publisher

New York: Nature Publishing Group US

Journal title

Nature neuroscience, 2006-12, Vol.9 (12), p.1520-1525

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Bace1 is an endopeptidase that cleaves the amyloid precursor protein at the β-secretase site. Apart from this cleavage, the functional importance of Bace1 in other physiological events is unknown. We show here that Bace1 regulates the process of myelination and myelin sheath thickness in the central and peripheral nerves. In
Bace1
-null mice,...

Alternative Titles

Full title

Bace1 modulates myelination in the central and peripheral nervous system

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_856760190

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_856760190

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/nn1797

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