Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT...
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Loss of IL-2 signaling results in autoimmunity. Laurence and colleagues show that the IL-2–STAT5 axis counteracts STAT3 activation of
Il17
to dampen IL-17 production independently of Foxp3.
Interleukin 2 (IL-2), a cytokine linked to human autoimmune disease, limits IL-17 production. Here we found that deletion of the gene encoding the tran...
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Full title
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
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TN_cdi_proquest_miscellaneous_860386298
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_860386298
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/ni.1995
