The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Josef Penninger and colleagues show that deletion of the stress kinase MKK7 in mouse models of lung and mammary tumors accelerates tumor onset and reduces overall survival. The study suggests that MKK7 is a sensor of oncogenic stress.
Most preneoplastic lesions are quiescent and do not progress to form overt tumors. It has been proposed that onc...
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The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
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TN_cdi_proquest_miscellaneous_860390107
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_860390107
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.767
