Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor...
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
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Author / Creator
Kotake, Y , Nakagawa, T , Kitagawa, K , Suzuki, S , Liu, N , Kitagawa, M and Xiong, Y
Publisher
England
Journal title
Language
English
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Publisher
England
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Scope and Contents
Contents
A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16(INK4A), p14(ARF) and p15(INK4B), and is altered in an estimated 30-40% of human tumors. The expression of the INK4A-ARF-INK4B gene cluster is silenced by polycomb during normal cell growth and is activated by oncogenic insults and during aging. How the polycom...
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Full title
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
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Record Identifier
TN_cdi_proquest_miscellaneous_863424370
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_863424370
Other Identifiers
E-ISSN
1476-5594
DOI
10.1038/onc.2010.568
